DOWNLOAD OUR APP
IndiaOnline playstore
08:29 PM | Tue, 30 Aug 2016

Download Our Mobile App

Download Font

Single drug dose can prevent early bone loss in HIV patients

188 Days ago

hiv 24216

New York: A single dose of the drug zoledronic acid was found to inhibit bone loss that is common in HIV-infected patients on antiretroviral therapy (ART), according to results of a phase two clinical trial.

"We are encouraged that our protocol was able to prevent bone loss in HIV patients on ART therapy," said study co-author Igho Ofotokun, associate professor of medicine at Emory University School of Medicine in Atlanta, US.

"These effects occurred early and last through 48 weeks, which is the period when ART-induced bone loss is most intense," Ofotokun noted. The findings were presented at the 2016 Conference on Retroviruses and Opportunistic Infections (CROI) in Boston, US.

The researchers studied HIV positive individuals, aged 30 to 50 years, who did not have osteoporosis, a disease that causes bone to become weak and brittle, and had no history of immunological disease other than HIV.

The researchers assessed 343 individuals for eligibility, and 63 were selected and randomised to receive either ART and placebo, or ART and zoledronic acid.

Treatment with zoledronic acid was associated with a 73 percent and a 65 percent reduction in bone loss relative to placebo at 12 weeks and 24 weeks respectively, an effect that lasted throughout the 48 weeks of the study.

Enhanced bone loss was seen in almost all participants in the placebo arm of the study, while no participant in the treatment arm had an appreciable rise in bone loss.

Bone loss was higher in men compared to women in the placebo arm, and the protection against bone loss was higher in men than in women in the treatment arm. Treatment did not impact the rate of viral suppression or immunologic response, the study said.  (IANS)

Viewed 102 times
  • SHARE THIS
  • TWEET THIS
  • SHARE THIS
  • E-mail
You might also want to read

Our Media Partners

app banner

REVOLUTIONARY ONE-STOP ALL-IN-1 MARKETING & BUSINESS SOLUTIONS

  • Digital Marketing
  • Website Designing
  • SMS Marketing
  • Catalogue Designing & Distribution
  • Branding
  • Offers Promotions
  • Manpower Hiring
  • Dealers
    Retail Shops
    Online Sellers

  • Distributors
    Wholesalers
    Manufacturers

  • Hotels
    Restaurants
    Entertainment

  • Doctors
    Chemists
    Hospitals

  • Agencies
    Brokers
    Consultants

  • Coaching Centres
    Hobby Classes
    Institutes

  • All types of
    Small & Medium
    Businesses

  • All types of
    Service
    Providers

FIND OUT MORE